Here rearrangements are induced by encounter with autoantigens to change specificity from self to non-self. Another example, receptor editing, is the means by which immature bone marrow B cells become self-tolerant 2, 3, 4. One familiar example of ongoing diversification is somatic mutation during clonal expansion 1.
This is hardly the case: B cell development is dependent on a series of error-prone, random rearrangement events that through ongoing diversification reach a compromise in which most cells are not autoreactive (except in disease) and the majority of clone members remain specific for the initial antigen. B cell development is often portrayed as a series of decision points that expand an antigen-reactive cell to a clone producing a single antibody.
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